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General Directions
Take metaxalone exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Medical Uses
Metaxalone is a muscle relaxant. Metaxalone is used, in conjunction with rest and physical therapy, to treat injuries and other painful muscular conditions. Metaxalone may also be used for purposes other than those listed.

Side Effects
If you experience any of the following serious side effects, stop taking metaxalone and seek emergency medical attention: an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives); or yellow skin or eyes. Other, less serious side effects may be more likely to occur. Continue to take metaxalone and talk to your doctor if you experience drowsiness or dizziness; headache, nervousness, or irritability; or nausea, upset stomach, or vomiting. Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

Precautions
Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking metaxalone. Use caution when driving, operating machinery, or performing other hazardous activities. Metaxalone may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.

Drug Interactions
Many drugs can increase the effects of metaxalone, which can lead to heavy sedation. Before taking this medication, tell your doctor if you are taking any of the following medicines: antihistamines such as brompheniramine (Dimetane, Bromfed, others), chlorpheniramine (Chlor-Trimeton, Teldrin, others), azatadine (Optimine), clemastine (Tavist), and many others; narcotics (pain killers) such as meperidine (Demerol), morphine (MS Contin, MSIR, others), propoxyphene (Darvon, Darvocet), hydrocodone (Lorcet, Vicodin), oxycodone (Percocet, Percodan), fentanyl (Duragesic), and codeine (Fiorinal, Fioricet, Tylenol #3, others); sedatives such as phenobarbital (Solfoton, Luminal), amobarbital (Amytal), and secobarbital (Seconal); phenothiazines such as chlorpromazine (Thorazine), fluphenazine (Prolixin), mesoridazine (Serentil), perphenazine (Trilafon), prochlorperazine (Compazine), thioridazine (Mellaril), and trifluoperazine (Stelazine); or antidepressants such as doxepin (Sinequan), imipramine (Tofranil), nortriptyline (Pamelor), fluoxetine (Prozac), paroxetine (Paxil), sertraline (Zoloft), phenelzine (Nardil), and tranylcypromine (Parnate). Drugs other than those listed here may also interact with metaxalone. Talk to your doctor or pharmacist before taking any prescription or over-the-counter medicines.

Missed Dose
Take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take only your next regularly scheduled dose. Do not take a double dose of this medication.

Storage
Store at room temperature away from moisture and heat. Keep this and all medications out of the reach of children.

Notes
Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking metaxalone. Use caution when driving, operating machinery, or performing other hazardous activities. Do not share metaxalone with others for whom it was not prescribed, since they may have a problem that is not effectively treated by this drug.

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