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General Directions

Most Common Medical Uses

Orphenadrine is a muscle relaxant. It works by blocking nerve impulses (or pain sensations) that are sent to your brain. Orphenadrine is commonly used, along with rest and physical therapy, to treat injuries and other painful muscular conditions. Orphenadrine may also be used for purposes other than those listed here.

How to Take This Medication

Take orphenadrine exactly as directed by your doctor. Take each dose with a full glass of water. Orphenadrine is usually taken two tablets per day; one in the morning and one in the evening. Follow your doctor's instructions. Do not crush or chew the extended-release tablets. Swallow them whole. They are specially formulated to release slowly in your body.

Possible Side Effects

Stop taking orphenadrine and seek emergency medical attention if you experience any of the following:an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives); an irregular or a very fast heartbeat; or confusion, hallucinations, or abnormal behavior. Other, less serious side effects may be more likely to occur. Continue to take orphenadrine and talk to your doctor if you experience dry mouth; drowsiness or dizziness; headache; tremor; blurred vision or large pupils. Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome

Precautions

Do not take orphenadrine if you have glaucoma, an obstruction or an ulcer in your stomach, an enlarged prostate or a blockage in your urinary tract (difficulty urinating), or myasthenia gravis. Before taking orphenadrine, tell your doctor if you have kidney disease, liver disease, or heart disease. You may need a lower dose or special monitoring during your therapy. Do not take orphenadrine without first talking to your doctor if you are pregnant or breast-feeding a baby. Orphenadrine is not approved for use in children.

Drug Interactions

Tell your doctor if you are taking amantadine (Symmetrel) before starting orphenadrine therapy. Orphenadrine and amantadine (Symmetrel) can both cause side effects such as dry mouth, difficulty urinating, constipation, blurred vision, and others. Together, these side effects may be more pronounced. Many drugs can increase the effects of orphenadrine, which can lead to heavy sedation. Before taking this medication, tell your doctor if you are taking any medicines. Drugs other than those listed here may also interact with orphenadrine. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

Missed Dose

Take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take only your next regularly scheduled dose. Do not take a double dose of this medication.

Storage

Store at room temperature away from moisture and heat. Keep this and all medications out of the reach of children.

Notes

Use caution when driving, operating machinery, or performing other hazardous activities. Orphenadrine may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities. Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking orphenadrine. Do not crush or chew the extended-release tablets. Swallow them whole. They are specially formulated to release slowly in your body. Never share your medications with others.

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